i2P Research has been serving in analytical R & D. We are expertise to undertake Chiral & Achiral impurities separation, isolation/purification projects. Our facility includes Instruments like LCMS/MS, HPLCs, Flash systems, Preparative HPLCs, DAC Columns for Purification and structural characterization of compounds. We also provide TGA, IR, 1D, 2D NMR along with different Nuclei NMR for characterisation.
i2P accepts Custom/Contract purification services by using scale up facilities, such as ereoea-)d DAC columns purification of Intermediates, APIs, Finished products, racemic mixtures- Chiral compounds, Impurities from mg to kg level scale.
A suitable tool to map the properties of pharmaceutical compound is direct insertion probe-mass spectrometry (DIP-MS), which works by placing samples directly into the ionization chamber without any prior processing, allowing them to vaporize, and then Ionizing them after electronic impact
The pharmaceutical, biotechnology and environmental industries use sophisticated analytical chemistry instruments known as liquid chromatography mass spectrometry (LC- MS).This apparatus allows for the very sensitive and accurate identification of a variety of compounds by combining the separation capabilities of high-pressure liquid chromatography (HPLC) with the mass analysis capabilities of mass spectrometry. Samples containing complicated combinations of substances are pumped into a chromatography column and separated into their constituent parts, primarily based on the polarity of the molecules. When a component reaches the end of a column, it is directed into an ion source, where the solvent is removed and the compounds are made ionized before being directed into a mass analyzer and mass detector. The mass detector affirms each ion’s abundance, and the mass analyzer organizes ions according to their masses(also known as the mass-to-charge ratio or m/z). Ions can be produced by a variety of sources each of which employs a somewhat different method.
The most powerful technique for determining the structure of organic compounds is nuclear magnetic resonance spectroscopy (NMR). The physical phenomenon of nuclear magnetic resonance (NMR) occurs when nuclei in a magnetic field absorb and re-emit electromagnetic radiation. This energy has a specific resonance frequency that is determined by the strength
Isolation, purification and characterization of compounds from milligrams to multi-grams and kilograms with help of Prep hPLC and Deck column.
Chiral purification milligrams to multi-kilograms and kilograms with prep-HPLC, with different chiral stationary phases and SFC
High throughput purification by PDA and MS-directed purification.
Final release of the shipments to the clients.
Reviewing of nonconforming outputs and deliverables
Review and authorization of certificates of analysis
Review and approval of specifications, and method of analysis.
Verification and approval of analytical instruments’ calibration schedules.
Approval of analyst qualification for major equipment like HPLC, LCMS, NMR, and GC, etc.